Electrophile versus oxidant modification of cysteine residues: Kinetics as a key driver of protein modification
Max B. Sauerland, Michael J. Davies
Abstract
. They may also induce similar or higher levels of modification than highly reactive oxidants, due to the very low concentrations of oxidants formed in most in vivo situations.
Topics & Concepts
ElectrophileChemistryAcroleinCysteineKineticsAdductReactivity (psychology)Medicinal chemistryBiochemistryCombinatorial chemistryOrganic chemistryEnzymePathologyPhysicsAlternative medicineMedicineQuantum mechanicsCatalysisGenomics, phytochemicals, and oxidative stressSynthesis and Biological EvaluationSulfur-Based Synthesis Techniques