Balancing fluorescence and singlet oxygen formation in push–pull type near-infrared BODIPY photosensitizers
Jasper Deckers, Tom Cardeynaels, Sandra Doria, Nikolay Tumanov, Andrea Lapini, Anitha Ethirajan, Marcel Ameloot, Johan Wouters, Mariangela Di Donato, Benoı̂t Champagne, Wouter Maes
Abstract
Rational, computationally guided, molecular design affords push–pull BODIPY photosensitizers with balanced brightness and phototoxicity for image-guided photodynamic therapy.
Topics & Concepts
BODIPYSinglet oxygenPhotodynamic therapyPhototoxicityPhotochemistryFluorescenceRational designMaterials scienceBrightnessPhotosensitizerPorphyrinOxygenCombinatorial chemistryOpticsNanotechnologyChemistryOrganic chemistryPhysicsBiochemistryIn vitroNanoplatforms for cancer theranosticsLuminescence and Fluorescent MaterialsPhotodynamic Therapy Research Studies