Nanoparticle delivery improves the pharmacokinetic properties of cyclic dinucleotide STING agonists to open a therapeutic window for intravenous administration
Mohamed Wehbe, Lihong Wang-Bishop, Kyle W. Becker, Daniel Shae, Jessalyn J. Baljon, Xinyi He, Plamen P. Christov, Kelli L. Boyd, Justin M. Balko, John T. Wilson
Topics & Concepts
StingStimulator of interferon genesPharmacologyPharmacokineticsChemistryImmune systemCancer immunotherapyNasal administrationImmunotherapyMedicineImmunologyInnate immune systemAerospace engineeringEngineeringinterferon and immune responsesImmune Response and InflammationCytomegalovirus and herpesvirus research