Photochemical Synthesis of Benzimidazoles from Diamines and Aldehydes
Elpida Skolia, Mary K. Apostolopoulou, Nikolaos F. Nikitas, Christoforos G. Kokotos
Abstract
Abstract An efficient, green, cheap, and metal‐free photochemical protocol for the synthesis of benzimidazoles has been developed. 2,2‐Dimethoxy‐2‐phenylacetophenone was employed as the photoinitiator and CFL lamps were used as the light source, leading to the cyclization of substituted diamines with aldehydes. The corresponding benzimidazoles were obtained in good to high yields. Mechanistic studies were conducted, in order to determine a plausible mechanism for the reaction.
Topics & Concepts
ChemistryPhotoinitiatorPhotochemistryReaction mechanismCombinatorial chemistryOrganic chemistryCatalysisPolymerMonomerRadical Photochemical ReactionsSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization Methods