The role of Sirtuin 1 and its activators in age-related lung disease
Chaoqun Sun, Shuyou Bai, Yanmei Liang, Dewei Liu, Jinyu Liao, Yujuan Chen, Xuanna Zhao, Bin Wu, Dan Huang, Min Chen, Dong Wu
Abstract
-dependent deacetylase that regulates inflammation and stress resistance. SIRT1 acts by inducing the deacetylation of various substrates and regulates several mechanisms that relate to lung aging, such as genomic instability, lung stem cell exhaustion, mitochondrial dysfunction, telomere shortening, and immune senescence. Chinese herbal medicines have many biological activities, exerting anti-inflammatory, anti-oxidation, anti-tumor, and immune regulatory effects. Recent studies have confirmed that many Chinese herbs have the effect of activating SIRT1. Therefore, we reviewed the mechanism of SIRT1 in age-related lung disease and explored the potential roles of Chinese herbs as SIRT1 activators in the treatment of age-related lung disease.