A comprehensive review of the therapeutic potential of citrus bioflavonoid hesperidin against lifestyle-related disorders
Aftab Ahmad, Muhammad Afzaal, Farhan Saeed, Shinawar Waseem Ali, Ali Imran, Syed Yaseen Raza Zaidi, Mohammad Saleem, Muzzamal Hussain, Entessar Al Jbawi
Abstract
The fruits of citrus family are rich in flavonoids with superior antioxidant properties; citrus bioactive components are potentially beneficial without adverse effects or cytotoxicity in healthy individuals. Citrus fruit peel contains ample amount of hesperidin which is flavanone glycoside and has showed effective role in biological systems as an antioxidant and anti-inflammatory bioactive compound. Different studies have investigated such roles of hesperidin. Due to superior antioxidant potential of hesperidin and its derivatives, these compounds have been intensively studied for their anti-cancer and cardio protective perspective. This review article is a collection of updated data covering different aspects of hesperidin and its derivatives, like occurrence, physical and chemical composition, pharmacokinetics and safety of these compounds. Moreover, effective role of these compounds against different lifestyle-related metabolic syndromes in mechanistic perspective has also been extensively discussed in this article.