In vitro development of imipenem/relebactam resistance in KPC-producing Klebsiella pneumoniae involves multiple mutations including OmpK36 disruption and KPC modification

Eva Gato, Paula Guijarro-Sánchez, Isaac Alonso-García, Rosa Pedraza-Merino, Adrián Ambroa Conde, Emilio Lence, Soraya Rumbo‐Feal, Andrea Peña-Escolano, Cristina Lasarte-Monterrubio, Tania Blanco-Martín, Ana Fernández-González, María del Carmen Fernández-López, Romina Maceiras, Marta Martínez-Guitián, Juan Carlos Vázquez-Ucha, Luis Martı́nez-Martı́nez, Concepción González‐Bello, Jorge Arca-Suárez, Alejandro Beceiro, Germán Bou