Head-to-Head Comparison of FDG and Radiolabeled FAPI PET: A Systematic Review of the Literature
Priscilla Guglielmo, Pierpaolo Alongi, Lucia Baratto, Elisabetta Abenavoli, Ambra Buschiazzo, Greta Celesti, Miriam Conte, Rossella Filice, Joana Gorica, Lorenzo Jonghi-Lavarini, Helena Lanzafame, Riccardo Laudicella, Maria Librando, Flavia Linguanti, Francesco Mattana, Alberto Miceli, Laura Olivari, Leandra Piscopo, Cinzia Romagnolo, Giulia Santo, Antonio Vento, Fabio Volpe, Laura Evangelista
Abstract
FAPI-based radiopharmaceuticals are a novel class of tracers, mainly used for PET imaging, which have demonstrated several advantages over [18F]FDG, especially in the case of low-grade or well-differentiated tumors. We conducted this systematic review to evaluate all the studies where a head-to-head comparison had been performed to explore the potential utility of FAPI tracers in clinical practice. FAPI-based radiopharmaceuticals have shown promising results globally, in particular in detecting peritoneal carcinomatosis, but studies with wider populations are needed to better understand all the advantages of these new radiopharmaceuticals.