Development of a generic zebrafish embryo PBPK model and application to the developmental toxicity assessment of valproic acid analogs
Ségolène Siméon, Katharina Brotzmann, Ciarán Fisher, Iain Gardner, Steve Silvester, Richard Maclennan, Paul Walker, Thomas Braunbeck, Frédéric Y. Bois
Topics & Concepts
Physiologically based pharmacokinetic modellingDevelopmental toxicityToxicityDanioPharmacokineticsZebrafishEmbryoChemistryValproic AcidPharmacologyToxicologyBiologyBiochemistryFetusCell biologyGeneticsGeneNeuroscienceEpilepsyPregnancyOrganic chemistryZebrafish Biomedical Research ApplicationsPharmacological Effects and Toxicity StudiesPharmaceutical and Antibiotic Environmental Impacts