PHLDA1 promotes glioblastoma cell growth via sustaining the activation state of Ras
Jiutao Wang, Ning Yao, Yamei Hu, Mingjuan Lei, Meixian Wang, Lu Yang, Satyananda Patel, Xiang Li, Kangdong Liu, Zigang Dong
Topics & Concepts
Proto-oncogene tyrosine-protein kinase SrcCancer researchCell growthMAPK/ERK pathwaySignal transductionDownregulation and upregulationPhosphorylationAnti-apoptotic Ras signalling cascadeGliomaOncogeneGlioblastomaCellChemistryTyrosine phosphorylationGTPaseCell cycleCell biologyBiologyBiochemistryGeneProtein Kinase Regulation and GTPase SignalingMicrotubule and mitosis dynamicsPI3K/AKT/mTOR signaling in cancer