Switching the proton-coupled electron transfer mechanism for non-canonical tyrosine residues in a <i>de novo</i> protein
Astrid Nilsen-Moe, Clorice R. Reinhardt, Ping Huang, Hemlata Agarwala, Rosana Lopes, Mauricio Lasagna, Starla D. Glover, Sharon Hammes‐Schiffer, Cecilia Tommos, Leif Hammarström
Abstract
Proton-coupled electron transfer reactions of tyrosine are instrumental to many redox reactions in nature. By balancing the driving forces for electron and proton transfer, the mechanism can be changed from step-wise to concerted transfer (CEPT).
Topics & Concepts
TyrosineElectron transferProtonChemistryMechanism (biology)Non canonicalBiophysicsStereochemistryPhotochemistryPhysicsBiochemistryBiologyQuantum mechanicsCell biologyPhotosynthetic Processes and MechanismsFree Radicals and AntioxidantsPhotochemistry and Electron Transfer Studies