Neutrophil Extracellular Traps in Atherosclerosis and Thrombosis
Thomas M. Hofbauer, Anna S. Ondracek, Iréne Lang
Abstract
Despite effective therapeutic and preventive strategies, atherosclerosis and its complications still represent a substantial health burden. Leukocytes and inflammatory mechanisms are increasingly recognized as drivers of atherosclerosis. Neutrophil granulocytes within the circulation were recently shown to undergo neutrophil extracellular trap (NET) formation, linking innate immunity with acute complications of atherosclerosis. In this chapter, we summarize mechanisms of NET formation, evidence for their involvement in atherosclerosis and thrombosis, and potential therapeutic regimens specifically targeting NET components.
Topics & Concepts
Neutrophil extracellular trapsThrombosisInnate immune systemImmunologyMedicineInflammationExtracellularImmune systemBiologyInternal medicineCell biologyNeutrophil, Myeloperoxidase and Oxidative MechanismsAtherosclerosis and Cardiovascular DiseasesCell Adhesion Molecules Research