Bromide Oxidation: A Safe Strategy for Electrophilic Brominations
Reinout Van Kerrebroeck, Tomas Horsten, Christian V. Stevens
Abstract
Abstract Bromination of organic substances is still an important reaction in modern synthetic chemistry. In view of the increasing demand for sustainable synthetic chemistry, oxidative bromination can play an important role to avoid the use of hazardous molecular bromine (Br 2 ). In this review, a complete overview of the chemical oxidants will be provided which have been used for the electrophilic as well as radical brominations, starting from less hazardous bromide Br(−I); e. g., HBr or a bromide salt, with a focus on the differences caused by the choice of oxidant.
Topics & Concepts
ChemistryBromineHalogenationElectrophileBromideHazardous wasteOrganic chemistryGreen chemistryElectrophilic substitutionCombinatorial chemistryReaction mechanismCatalysisWaste managementEngineeringVanadium and Halogenation ChemistryOxidative Organic Chemistry ReactionsChemical Synthesis and Reactions