Benzyloxycalix[8]arene supported Pd–NHC cinnamyl complexes for Buchwald–Hartwig C–N cross-couplings
Sandra Abi Fayssal, Timothée Naret, Vincent Huc, Julien Buendia, Cyril Martini, Emmanuelle Schulz
Abstract
The synthesis of a Pd–NHC cinnamyl-complex supported on a calix[8]arene and its use in Buchwald–Hartwig amination is reported. Thanks to the support, the products were isolated with low levels of residual palladium, in some cases below standards.
Topics & Concepts
AminationPalladiumChemistryCatalysisResidualCombinatorial chemistryMedicinal chemistryOrganic chemistryComputer scienceAlgorithmCatalytic Cross-Coupling ReactionsOrganoboron and organosilicon chemistryN-Heterocyclic Carbenes in Organic and Inorganic Chemistry