Impairment of mitochondrial quality control exacerbates diabetes-related atrial fibrillation by cGAS-STING signaling pathway and cardiomyocyte-macrophage crosstalk
Shan Meng, Jinfeng Duan, Jikai Zhao, Zijun Zhou, Boxuan Sun, Yinli Xu, Tao Huang, Tao Hong, Xin Chen, Tong Su, Liming Yu, Huishan Wang
Abstract
Impairment of mitochondrial quality control promotes atrial inflammation and remodeling in diabetes through mtDNA-induced cGAS-STING activation and cardiomyocyte-macrophage communication. Targeting this pathway may offer a novel strategy for AF management in metabolically compromised hearts.
Topics & Concepts
Mitochondrial ROSInflammationMitochondrionAtrial fibrillationCrosstalkDiabetic cardiomyopathySignal transductionGene knockdownCell biologyOxidative phosphorylationOxidative stressMedicineMitochondrial DNAInternal medicineDiabetes mellitusStreptozotocinEndocrinologymitochondrial fusionReactive oxygen speciesProinflammatory cytokineInsulin resistancePharmacologyBiologyMitochondrial permeability transition poreInsulinApoptosisChemistrySOCS3Insulin receptorinterferon and immune responsesCardiovascular Disease and AdiposityAtrial Fibrillation Management and Outcomes