Homoharringtonine inhibits the NOTCH/MYC pathway and exhibits antitumor effects in T-cell acute lymphoblastic leukemia
Shanshan Suo, Dandan Zhao, Fenglin Li, Yi Zhang, Sonia Rodriguez‐Rodriguez, Le Xuan Truong Nguyen, Lucy Ghoda, Nadia Carlesso, Guido Marcucci, Bin Zhang, Jie Jin
Abstract
ABSTRACT: We report on the antileukemic activity of homoharringtonine (HHT) in T-cell acute lymphoblastic leukemia (T-ALL). We showed that HHT inhibited the NOTCH/MYC pathway and induced significantly longer survival in mouse and patient-derived T-ALL xenograft models, supporting HHT as a promising agent for T-ALL.
Topics & Concepts
HomoharringtonineLymphoblastic LeukemiaCancer researchLeukemiaNotch signaling pathwayMedicineVincristineMyeloid leukemiaImmunologyInternal medicineChemotherapyReceptorCyclophosphamideAcute Lymphoblastic Leukemia researchT-cell and Retrovirus StudiesChronic Myeloid Leukemia Treatments