Microsatellite instability and immunotherapy in gastric cancer: a narrative review
Yantao Duan, Dazhi Xu
Abstract
Background and Objective: Immunotherapy is now a new treatment approach that is widespreadly accepted in the clinical practice, but the role in gastric cancer is still poorly elaborated. As mentioned in The Cancer Genome Atlas (TCGA) and Asian Cancer Research Group (ACRG) cancer classifications, the separate microsatellite instable (MSI) entirety is defined as a specific subtype of gastric cancer. In particular, the MSI hypermutator phenotype gastric cancer triggers immune response, allowing the specific molecular subset as a potential candidate for immunotherapy. The current review is to provide an updated overview of the available literature on the clinical implications of MSI in gastric cancer.
Topics & Concepts
Microsatellite instabilityCancerImmunotherapyCancer immunotherapyMedicineOncologyBiologyBioinformaticsMicrosatelliteInternal medicineGeneticsGeneAlleleGenetic factors in colorectal cancerCancer Immunotherapy and BiomarkersCholangiocarcinoma and Gallbladder Cancer Studies