ATP Promotes Oral Squamous Cell Carcinoma Cell Invasion and Migration by Activating the PI3K/AKT Pathway via the P2Y2-Src-EGFR Axis
Qin Zhou, Shanshan Liu, Yuying Kou, Panpan Yang, Hongrui Liu, Tomoka Hasegawa, Rongjian Su, Guoxiong Zhu, Minqi Li
Abstract
. The PI3K/AKT signaling pathway was blocked by Src or EGFR inhibitor. Extracellular ATP activates the PI3K/AKT pathway through the P2Y2-Src-EGFR axis to promote OSCC invasion and migration, and thus, P2Y2 may be a potential novel target for antimetastasis therapy.
Topics & Concepts
Protein kinase BPI3K/AKT/mTOR pathwayCancer researchProto-oncogene tyrosine-protein kinase SrcCancerCell migrationCancer cellChemistryBiologyKinaseCellSignal transductionMedicineCell biologyInternal medicineBiochemistryAdenosine and Purinergic SignalingNeuroendocrine Tumor Research AdvancesLung Cancer Research Studies