Exploration of the mechanism of action of cenobamate
Raman Sankar, Louis Ferrari, Marc Kamin
Abstract
currents. These combined mechanistic effects may represent an emerging class of ASMs and could explain cenobamate's broad-spectrum effect in animal seizure models and its efficacy for focal seizures in humans. In this review, we examine how cenobamate interacts with sodium currents and GABA receptor physiology and review cenobamate's efficacy profile in humans. Finally, we will postulate how specific aspects of cenobamate's dual MoA may contribute to its efficacy in comparison to other ASMs with similar MoAs.
Topics & Concepts
Sodium channelTonic (physiology)Allosteric regulationNeurosciencePharmacologySodium channel blockerMechanism of actionChemistryIon channelDravet syndromeConvulsantReceptorPotentiatorSodiumEpilepsyAnticonvulsantAllosteric modulatorNeurotransmitterChannelopathyGABAA receptorMechanism (biology)Site of actionMedicineClonazepamElectrophysiologyInhibitory postsynaptic potentialEpilepsy research and treatmentNeuroscience and Neuropharmacology ResearchAnesthesia and Sedative Agents