A carbazole functionalized semiconducting compound as a heavy atom free photosensitizer for phototherapy against lung cancer
Jun Deng, Ning Zhong, Xiaochuan Zhang, Chang Li, C. F. Xu, Jun Zhao
Abstract
towards human lung cancer cells (A549) with irradiation while the dark toxicity is almost negligible even at high concentrations. Furthermore, in vivo photothermal imaging guided study demonstrates that these NPs are able to inhibit tumor growth with the help of laser. The H&E stained pictures of the normal tissues indicate the biosafety of DPPCz NPs in that no obvious damage was observed. Our results demonstrate that DPPCz NPs are potential semiconducting photosensitizers for phototheranostics.
Topics & Concepts
PhotosensitizerPhotothermal therapyCarbazoleMaterials sciencePhotochemistryNanotechnologyAtom (system on chip)ChemistryComputer scienceEmbedded systemNanoplatforms for cancer theranosticsAdvanced Photocatalysis TechniquesLuminescence and Fluorescent Materials