Biointerface Between ZIF-8 and Biomolecules and their Applications
Hani Nasser Abdelhamid, H Zhou, J Long, O Yaghi, H Furukawa, K Cordova, M O'keeffe, O Yaghi, C Trickett, A Helal, B Al-Maythalony, Z Yamani, K Cordova, O Yaghi, H Furukawa, N Ko, Y Go, N Aratani, S Choi, E Choi, A Yazaydin, R Snurr, M O'keeffe, J Kim, O Yaghi, A Abdellah, H Abdelhamid, A El-Adasy, A Atalla, K Aly, H Abdelhamid, Q Yao, A Bermejo Gmez, J Su, V Pascanu, Y Yun, H Zheng, H Chen, L Liu, H Abdelhamid, B Martn-Matute, X Zou, H Abdelhamid, A Bermejo-Gmez, B Martn-Matute, X Zou, Y Yang, K Shen, J Lin, Y Zhou, Q Liu, C Hang, H Abdelhamid, Z Zhang, H Chen, H Abdelhamid, M Wilk-Kozubek, A El-Zohry, A Bermejo Gmez, A Valiente, B Martn-Matute, A Mudring, X Zou, H Emam, H Abdelhamid, R Abdelhameed, H Abdelhamid, H Abdelhamid, H Wu, H Abdelhamid, H Abdelhamid, H Wu, H Abdelhamid, H Abdelhamid, A Kassem, H Abdelhamid, D Fouad, S Ibrahim, M Goda, H Abdelhamid, A Said, X Zhang, G Li, D Wu, X Li, N Hu, J Chen, G Chen, Y Wu, I Imaz, M Rubio-Martnez, J An, I Sol-Font, N Rosi, D Maspoch, C Doonan, R Ricc, K Liang, D Bradshaw, P Falcaro
Abstract
This review summarized the recent progress of biointerface between zeolitic imidazolate frameworks (ZIF-8) and biological species such as protein, peptides, viruses, cells, and tissues. ZIF-8 has been widely conjugated with bio-entities offering remarkable loading capacity, high chemical stability in physiological environments, and tunable drug release properties. There are several methods to encapsulate biological species into ZIF-8. The synthesis methods such as one-pot synthesis and post-synthetic modification are widely used for the conjugation of biological species and ZIF-8. The biointerface interactions between the biomolecules and ZIF-8 precursors enhanced the synthesis procedure and improved the yield and the properties of the final products. Two enzymes and hybrid conjugation of enzyme and a nanoparticle were also reported. These combinations offered dual functions and provided extra properties such as simple separation of the materials after uses. A brief discussion of the applications of ZIF-8 biocomposite was also covered. This review allowed the readers to acquire insights into the importance of ZIF-8 for the immobilization of biomolecules for biomedicine.