Tumor microbiota of renal cell carcinoma affects clinical prognosis by influencing the tumor immune microenvironment
Hengyi Xu, Jingze Leng, Fengshuo Liu, Tianxiang Chen, Jiangming Qu, Yufan Yang, Chun Ning, Xindi Ke, Bin Xiao, Yanbin Zhang, Lejia Sun
Abstract
). Employing Cox regression analysis and support vector machines, a prognosis-related microbiome risk signature was developed, achieving an AUC of 0.809. Based on this risk signature, two microbiome-based subtypes were found to be significantly associated with distinct clinical prognoses and immune microenvironments. These findings were corroborated by significant correlations between prognostic-relevant microorganisms and 30 immune-related differentially expressed genes. Specifically, microbial genera associated with a negative prognosis were linked to a pro-tumor acute inflammatory immune response, whereas genera related to a positive prognosis were associated with an anti-tumor adaptive immune response. In conclusion, microbiome-based subtyping revealed correlations between tumor microbiome, clinical prognosis, and tumor microenvironment, indicating intratumoral microbiota as a promising prognostic biomarker for kidney renal clear cell carcinoma.