Cimigenoside functions as a novel γ-secretase inhibitor and inhibits the proliferation or metastasis of human breast cancer cells by γ-secretase/Notch axis
Hui Jia, Mingyue Liu, Xinying Wang, Qiyu Jiang, Shu Wang, Ramesh Kumar Santhanam, Chongning Lv, Qingchun Zhao, Jincai Lu
Topics & Concepts
Breast cancerNotch signaling pathwayCancer researchMetastasisEpithelial–mesenchymal transitionApoptosisGamma secretaseCancerIn vivoCancer cellChemistryBiologyMedicineSignal transductionCell biologyInternal medicineBiochemistryBiotechnologySynthesis and Biological ActivityMarine Sponges and Natural ProductsBioactive Compounds and Antitumor Agents