TRPC6 N338S is a gain-of-function mutant identified in patient with doxorubicin-induced cardiotoxicity
Tong Lü, Xiaojing Sun, Brian M. Necela, Hon-Chi Lee, Nadine Norton
Topics & Concepts
TRPC6CardiotoxicityMutantDoxorubicinIntracellularPharmacologyActivator (genetics)ChemistryCancer researchCell biologyBiologyTransient receptor potential channelBiochemistryGeneGeneticsChemotherapyReceptorIon Channels and ReceptorsIon channel regulation and functionChemotherapy-induced cardiotoxicity and mitigation