SERCA and P-glycoprotein inhibition and ATP depletion are necessary for celastrol-induced autophagic cell death and collateral sensitivity in multidrug-resistant tumor cells
Su Xu, Betty Yuen Kwan Law, Steven Li Qun Qu, Sami Hamdoun, Juan Chen, Wei Zhang, Jian-Ru Guo, Anguo Wu, Simon Wing Fai Mok, David Wei Zhang, Chenglai Xia, Yoshikazu Sugimoto, Thomas Efferth, Liang Liu, Vincent Kam Wai Wong
Topics & Concepts
SERCACancer cellCelastrolP-glycoproteinCancer researchCell biologyEndoplasmic reticulumChemistryMultiple drug resistanceApoptosisPharmacologyBiologyCancerBiochemistryATPaseMedicineInternal medicineEnzymeAntibioticsDrug Transport and Resistance MechanismsNatural Compounds in Disease TreatmentNatural product bioactivities and synthesis