Immunodeficiency syndromes differentially impact the functional profile of SARS-CoV-2-specific T cells elicited by mRNA vaccination
Yu Gao, Curtis Cai, David Wullimann, Julia Niessl, Olga Rivera‐Ballesteros, Puran Chen, Joshua Lange, Angélica Cuapio, Ola Blennow, Lotta Hansson, Stephan Mielke, Piotr Nowak, Jan Vesterbacka, Mira Akber, André Perez‐Potti, Takuya Sekine, Thomas Müller, Caroline Boulouis, Tobias Kammann, Tiphaine Parrot, Jagadeeswara Rao Muvva, Michał J. Sobkowiak, Katie Healy, Gordana Bogdanović, Sandra Muschiol, Gunnar Söderdahl, Anders Österborg, Fredrika Hellgren, Alba Grifoni, Daniela Weiskopf, Alessandro Sette, Karin Loré, Margaret Chen, Per Ljungman, Johan K. Sandberg, C.I. Edvard Smith, Peter Bergman, Hans‐Gustaf Ljunggren, Soo Aleman, Marcus Buggert
Abstract
T cells with stem-like characteristics. Collectively, our data provide the functional continuum of SARS-CoV-2-specific T cell responses post-mRNA vaccination, highlighting that cell-mediated immunity is of variable functional quality across immunodeficiency syndromes.