CRISPRi/a screens in human iPSC-cardiomyocytes identify glycolytic activation as a druggable target for doxorubicin-induced cardiotoxicity
Chunying Liu, Mengcheng Shen, Yanxia Liu, Amit Manhas, Rui Zhao, Mao Zhang, Nadjet Belbachir, Lu Ren, Joe Z. Zhang, Arianne Caudal, Masataka Nishiga, Dilip Thomas, Angela Zhang, Huaxiao Yang, Yang Zhou, Mohamed Ameen, Nazish Sayed, June‐Wha Rhee, Lei S. Qi, Joseph C. Wu
Topics & Concepts
DruggabilityBiologyCardiotoxicityGlycolysisDoxorubicinCancer researchInduced pluripotent stem cellComputational biologyCell biologyBioinformaticsBiochemistryGeneticsGeneEnzymeChemotherapyEmbryonic stem cellSemiconductor materials and devicesChemotherapy-induced cardiotoxicity and mitigationElectrochemical sensors and biosensors