Proteome-wide Mendelian randomization implicates nephronectin as an actionable mediator of the effect of obesity on COVID-19 severity
Satoshi Yoshiji, Guillaume Butler‐Laporte, Tianyuan Lu, Julian Willett, Chen‐Yang Su, Tomoko Nakanishi, David Morrison, Yiheng Chen, Kevin Y. H. Liang, Michael Hultström, Yann Ilboudo, Zaman Afrasiabi, Shanshan Lan, Naomi Duggan, Chantal DeLuca, Mitra Vaezi, Chris Tselios, Xiaoqing Xue, Meriem Bouab, Fangyi Shi, Lætitia Laurent, Hans Markus Münter, Marc Afilalo, Jonathan Afilalo, Vincent Mooser, Nicholas J. Timpson, Hugo Zeberg, Sirui Zhou, Vincenzo Forgetta, Yossi Farjoun, J. Brent Richards
Topics & Concepts
Mendelian randomizationMediatorObesityBody mass indexBiologyCoronavirus disease 2019 (COVID-19)BioinformaticsTranscriptomeInternal medicineProteomeMedicineDiseaseGeneEndocrinologyGeneticsGene expressionGenetic variantsInfectious disease (medical specialty)GenotypeSingle-cell and spatial transcriptomicsDiabetes and associated disordersCOVID-19 Clinical Research Studies