Dynamic Augmentation of Left Ventricle and Mitral Valve Function With an Implantable Soft Robotic Device
Mossab Y. Saeed, David Van Story, Christopher J. Payne, Isaac Wamala, Borami Shin, Daniel Bautista‐Salinas, David Zurakowski, Pedro J. del Nido, Conor J. Walsh, Nikolay V. Vasilyev
Abstract
Left ventricular failure is strongly associated with secondary mitral valve regurgitation. Implantable soft robotic devices are an emerging technology that enables augmentation of a native function of a target tissue. We demonstrate the ability of a novel soft robotic ventricular assist device to dynamically augment left ventricular contraction, provide native pulsatile flow, simultaneously reshape the mitral valve apparatus, and eliminate the associated regurgitation in an Short-term large animal model of acute left ventricular systolic dysfunction.
Topics & Concepts
VentricleCardiologyPulsatile flowInternal medicineMedicineMitral valveSoft roboticsMitral valve regurgitationVentricular functionFunctional mitral regurgitationMitral regurgitationHeart failureVentricular assist deviceBiomedical engineeringComputer scienceActuatorArtificial intelligenceEjection fractionCardiac Valve Diseases and TreatmentsCardiac Structural Anomalies and RepairMechanical Circulatory Support Devices