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Experimental and real-world evidence supporting the computational repurposing of bumetanide for APOE4-related Alzheimer’s disease

Alice Taubes, Phil Nova, Kelly A. Zalocusky, Idit Kosti, Mesude Bicak, Misha Zilberter, Yanxia Hao, Seo Yeon Yoon, Tomiko Oskotsky, Sílvia Pineda, Bin Chen, Emily A Aery Jones, Krishna Choudhary, Brian P. Grone, Maureen E. Balestra, Fayzan Chaudhry, Ishan Paranjpe, Jessica De Freitas, Nicole Koutsodendris, Nuo Chen, Celine Wang, William Chang, Alice An, Benjamin S. Glicksberg, Marina Sirota, Yadong Huang

2021Nature Aging112 citationsDOIOpen Access PDF

Topics & Concepts

RepurposingBumetanideDiseaseAlzheimer's diseaseMedicineComputer scienceNeurosciencePsychologyInternal medicineEngineeringBiologyWaste managementIon transporterGeneticsMembraneAlzheimer's disease research and treatmentsComputational Drug Discovery MethodsMitochondrial Function and Pathology
Experimental and real-world evidence supporting the computational repurposing of bumetanide for APOE4-related Alzheimer’s disease | Litcius