Enlarging the substrate binding pocket of penicillin G acylase from Achromobacter sp. for highly efficient biosynthesis of β-lactam antibiotics
Zhen Yan, Bin Huang, Kai Yang, Richmond Anaman, Charles Amanze, Jing Jin, Hongbo Zhou, Guanzhou Qiu, Weimin Zeng
Topics & Concepts
ChemistryHydrolysisCombinatorial chemistryPenicillinStereochemistryBarbituric acidLactamMutantBiocatalysisSubstrate (aquarium)BiochemistryAntibioticsCatalysisGeneIonic liquidGeologyOceanographyEnzyme Catalysis and ImmobilizationEnzyme Production and CharacterizationSteroid Chemistry and Biochemistry