Ultrasound-Driven Biomimetic Nanosystem Suppresses Tumor Growth and Metastasis through Sonodynamic Therapy, CO Therapy, and Indoleamine 2,3-Dioxygenase Inhibition
Da Zhang, Ziguo Lin, Youshi Zheng, Jibin Song, Juan Li, Yongyi Zeng, Xiaolong Liu
Abstract
/CO therapy, then can achieve effective immune responses and long-term immune memory through the combination of indoleamin 2,3-dioxygenase (IDO) signal blocking to effectively against tumor rechallenge and prevent lung metastasis. Taken together, the here-presented therapeutic strategy based on sonodynamic/CO therapy and IDO signaling inhibition might provide a promising perspective for synergistically treating cancer in future clinical translations.
Topics & Concepts
Sonodynamic therapyCancer researchTumor microenvironmentIndoleamine 2,3-dioxygenaseMetastasisImmune systemImmunotherapyMedicineChemistryReactive oxygen speciesImmunologyBiologyCell biologyCancerTumor cellsAmino acidTryptophanInternal medicineBiochemistryNanoplatforms for cancer theranosticsCancer, Stress, Anesthesia, and Immune ResponseBrain Metastases and Treatment