Computation-Aided Engineering of Cytochrome P450 for the Production of Pravastatin
Mark Ashworth, Elvira Bombino, René M. de Jong, Hein J. Wijma, Dick B. Janssen, Kirsty J. McLean, Andrew W. Munro
Abstract
framework for specificity engineering of enzymes of known structure.
Topics & Concepts
StereoselectivityChemistryPravastatinHydroxylationStereochemistryIn silicoVirtual screeningMutagenesisBiocatalysisMutantCombinatorial chemistryEnzymeBiochemistryCatalysisReaction mechanismGenePharmacophoreCholesterolMicrobial Natural Products and BiosynthesisPlant biochemistry and biosynthesisComputational Drug Discovery Methods