Acetylation of Lactate Dehydrogenase Negatively Regulates the Acidogenicity of Streptococcus mutans
Qizhao Ma, Yangyang Pan, Yang Chen, Shuxing Yu, Jun Huang, Yaqi Liu, Tao Gong, Qiong Zhang, Qun Sun, Jing Zou, Yuqing Li
Abstract
-acetyltransferases (GNAT) family in S. mutans, acetylated LDH, inhibited its enzymatic ability to catalyze the conversion of pyruvate to lactic acid, and impaired its cariogenicity in a rat caries model. Therefore, LDH acetylation might be a potential target that can be exploited in the design of novel therapeutics to prevent dental caries.
Topics & Concepts
AcetylationStreptococcus mutansBacteriaLysineLactate dehydrogenaseChemistryMicrobiologyBiochemistryBiologyEnzymeAmino acidGeneGeneticsOral microbiology and periodontitis researchAntimicrobial Peptides and ActivitiesPeptidase Inhibition and Analysis