In situ click chemistry-based discovery of 1,2,3-triazole-derived diarylpyrimidines as novel HIV-1 NNRTIs by exploiting the tolerant region I in binding pocket
Yanying Sun, Da Feng, Zhenzhen Zhou, Tao Zhang, Erik De Clercq, Christophe Pannecouque, Dongwei Kang, Peng Zhan, Xinyong Liu
Topics & Concepts
ChemistryClick chemistryTriazoleReverse transcriptaseCombinatorial chemistryHydrogen bondStereochemistryIn situHuman immunodeficiency virus (HIV)Reverse-transcriptase inhibitorMolecular modelBinding pocket1,2,3-TriazoleDrug discoveryEnzymeMoleculeBiochemistryVirologyRNAOrganic chemistryBiologyGeneHIV/AIDS drug development and treatmentHIV Research and TreatmentClick Chemistry and Applications