Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy
Wenbo Yin, Lei Liu, Hong Jiang, Tianxiao Wu, Hengxian Cui, Yuxin Zhang, Zixuan Gao, Yin Sun, Qiaohua Qin, Liyu Zhao, Xin Su, Dongmei Zhao, Maosheng Cheng
Topics & Concepts
ChemistryAzoleFungicideThiopheneLead compoundDrugAntifungal drugReagentCombinatorial chemistryDrug resistanceAntifungalEchinocandinsPharmacologyMicrobiologyAmphotericin BBiochemistryIn vitroOrganic chemistryBiologyCaspofunginBotanyAntifungal resistance and susceptibilitySynthesis and Biological EvaluationSynthesis and biological activity