T cell factor 1: A master regulator of the T cell response in disease
Giulia Escobar, Davide Mangani, Ana C. Anderson
Abstract
Recent advances have redefined a role for T cell factor 1 (TCF1) that goes beyond T cell development and T memory formation and encompasses new functions in the regulation of T cell biology. Here, we discuss the multifaceted and context-dependent role of TCF1 in peripheral T cells, particularly during disease-induced inflammatory states such as autoimmunity, cancer, and chronic infections. Understanding how TCF1 fine-tunes peripheral T cell biology holds the potential to tailor improved immune-targeted therapies.
Topics & Concepts
Master regulatorAutoimmunityRegulatorBiologyT cellImmune systemCellContext (archaeology)DiseaseCell biologyImmunologyTranscription factorNeuroscienceMedicineGeneticsGenePathologyPaleontologyImmune Cell Function and InteractionCAR-T cell therapy researchT-cell and B-cell Immunology