An update on the role of long non-coding RNAs in psoriasis
Jiankun Song, Shuangyi Yin, Wei Li, Xiaodong Li, Yue Luo, Ying Luo, Meng Xing, Bin Li, Le Kuai
Abstract
ABSTRACT: Increasing evidence suggests that long non-coding RNAs (lncRNAs) are of vital importance for various biological processes, and dysregulation of lncRNAs is frequently associated with various diseases such as psoriasis. LncRNAs modulate gene expression at the transcriptional, post-transcriptional, and translational levels; however, the specific regulatory mechanisms of lncRNAs in psoriasis remain largely unexplored. This review provides an overview of recent studies investigating mechanisms and functions of lncRNAs in psoriasis, especially focusing on the role of lncRNAs in keratinocytes, T cells, and dendritic cells.
Topics & Concepts
PsoriasisCoding (social sciences)Computational biologyLong non-coding RNAMedicineBiologyBioinformaticsRNAGeneticsDermatologyMathematicsGeneStatisticsCancer-related molecular mechanisms researchMycobacterium research and diagnosisCytokine Signaling Pathways and Interactions