Neuroprotective Effect of Epalrestat on Hydrogen Peroxide-Induced Neurodegeneration in SH-SY5Y Cellular Model
Sivakumar Lingappa, Muthugounder Subramanian Shivakumar, Thamilarasan Manivasagam, S. T. Somasundaram, Palaniappan Seedevi
Abstract
Alzheimer's disease (AD) is one of the most common chronic neurodegenerative diseases and is associated with two types of pathological hallmarks in the brain. These biomarkers are extracellular plaque deposits mainly composed by amyloid-beta (A) peptides and intracellular neurofibrillary tangles (NFT) formed by tau hyperphosphorylation A peptides are deposited through enzymatic cleavage of amyloid precursor protein (APP) by and -secretase enzymes In 2017, the Alzheimer's Association surveyed the AD population worldwide and found 48 million people with early symptoms of the disease. The prevalence of the disease is expected to double by 2050. The most common symptoms are short-term memory loss, difficulty in finding words, trouble with visual-spatial understanding, reasoning, judgment and insight.