Mechanistic insights into bismuth(<scp>iii</scp>) inhibition of SARS-CoV-2 helicase
Xueying Wei, Chun-Lung Chan, Ying Zhou, Kaiming Tang, Jingxin Chen, Suyu Wang, Jasper Fuk‐Woo Chan, Shuofeng Yuan, Hongyan Li, Hongzhe Sun
Abstract
of 1.18 ± 0.09 μM with a selective index of 847 in VeroE6-TMPRSS2 infected cells. This study highlights the important role of helicase for the development of more effective antiviral drugs to combat SARS-CoV-2 infection.
Topics & Concepts
HelicaseBismuthChemistryCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Computational biologyRNA Helicase AVirologyCell biologyBiochemistryBiologyMedicineRNAGeneDiseaseInfectious disease (medical specialty)PathologyOrganic chemistryRNA and protein synthesis mechanismsViral Infections and Immunology ResearchMonoclonal and Polyclonal Antibodies Research