A new synthetic protectin D1 analog 3-oxa-PD1<sub>n-3 DPA</sub> reduces neuropathic pain and chronic itch in mice
Jannicke Irina Nesman, Chen Ouyang, Xin Luo, Ru‐Rong Ji, Charles N. Serhan, Trond Vidar Hansen
Abstract
The novel protectin D1 analog 3-oxa-PD1<sub>n-3 DPA</sub> was synthesized. Nanogram amounts of this analog reduces neuropathic pain and chronic itch, and shows analgesic action in a mouse model of diabetic neuropathy.
Topics & Concepts
Neuropathic painChemistryAnalgesicPharmacologyChronic painDiabetic neuropathyNeuroscienceMedicineDiabetes mellitusEndocrinologyPsychologyPain Mechanisms and TreatmentsPharmacological Effects of Natural CompoundsBiochemical effects in animals