Excitation properties of computational models of unmyelinated peripheral axons
Nicole A. Pelot, David Catherall, Brandon J. Thio, Nathan D. Titus, Edward D. Liang, Craig S. Henriquez, Warren M. Grill
Abstract
Peripheral nerves are primarily composed of unmyelinated axons, and there is growing interest in electrical stimulation of the autonomic nervous system to treat various diseases. We present the first cable model of an unmyelinated vagal nerve fiber and compare its ion channel isoforms and conduction responses with other published models of unmyelinated axons, establishing important tools for advancing modeling of autonomic nerves.
Topics & Concepts
NeuroscienceStimulationPeripheralPeripheral nervous systemChemistryAnatomyCentral nervous systemMedicineBiologyInternal medicinePhotoreceptor and optogenetics researchNeuroscience and Neural EngineeringNeural dynamics and brain function