An Updated Review of Hypertrophic Scarring
Manjula P. Mony, Kelly A. Harmon, Ryan Falcone Hess, Amir H. Dorafshar, Sasha H. Shafikhani
Abstract
Hypertrophic scarring (HTS) is an aberrant form of wound healing that is associated with excessive deposition of extracellular matrix and connective tissue at the site of injury. In this review article, we provide an overview of normal (acute) wound healing phases (hemostasis, inflammation, proliferation, and remodeling). We next discuss the dysregulated and/or impaired mechanisms in wound healing phases that are associated with HTS development. We next discuss the animal models of HTS and their limitations, and review the current and emerging treatments of HTS.
Topics & Concepts
Wound healingExtracellular matrixMedicineInflammationConnective tissueHemostasisPathologyBioinformaticsBiologySurgeryCell biologyImmunologyWound Healing and TreatmentsDermatologic Treatments and ResearchPeriodontal Regeneration and Treatments