A Cd9+Cd271+ stem/progenitor population and the SHP2 pathway contribute to neonatal-to-adult switching that regulates tendon maturation
Chunmei Fan, Yanyan Zhao, Yangwu Chen, Tian Qin, Junxin Lin, Shan Han, Ruojin Yan, Tingyun Lei, Yuanhao Xie, Tingzhang Wang, Shen Linda Gu, Hongwei Ouyang, Weiliang Shen, Zi Yin, Xiao Chen
Abstract
tendon stem/progenitor cell population mainly prompts conversion from neonate to adult tendon. Through single-cell gene regulatory network analysis, in vitro inhibitor identification, and in vivo tendon-specific Shp2 deletion, we find that SHP2 signaling is a regulator for tendon maturation. Our research comprehensively reveals the dynamic cell population transition during tendon maturation, implementing insights into the critical roles of the maturation-related stem cell population and SHP2 signaling pathway during tendon differentiation and regeneration.