Comparison of drug release behavior of bacterial cellulose loaded with ibuprofen and propranolol hydrochloride
Chutima Jantarat, Poowadon Muenraya, Suthon Srivaro, Ananya Nawakitrangsan, Korntep Promsornpason
Abstract
for propranolol hydrochloride. The drug-loaded BC prepared by the freeze-drying method showed a sustained release regardless of drug type and drug-loaded amount. The sustained release followed the Higuchi and Korsmeyer-Peppas models. On the other hand, when using the air-drying method, BC loaded with ibuprofen showed immediate release at every drug-loaded amount. However, BC loaded with propranolol hydrochloride showed immediate release at the high drug-loaded amount but showed sustained release at the low drug-loaded amount. The release of drug from a drug-loaded BC prepared by air-drying method tended to follow first-order kinetics. In conclusion, the drug loading concentration and the drying method in the drug-loaded BC preparation influenced the drug release characteristics of the BC-based drug delivery system.