Electrochemical 5-<i>exo-dig</i> aza-cyclization of 2-alkynylbenzamides toward 3-hydroxyisoindolinone derivatives
Zhaojiang Shi, Nan Li, Weizhen Wang, Hao‐Kuan Lu, Yaofeng Yuan, Zhen Li, Ke‐Yin Ye
Abstract
radical cyclization to form 3-hydroxyisoindolinone derivatives. This reaction features simple operation, good selectivity, and broad substrate scope. Moreover, gram-scale preparation and synthetic elaborations imply the potential applicability of this protocol for the synthesis of diverse isoindolinone derivatives.
Topics & Concepts
DigChemistryCombinatorial chemistrySubstrate (aquarium)Scope (computer science)ElectrochemistryRadical cyclizationReaction conditionsSelectivityOrganic chemistryCatalysisComputer scienceElectrodeOceanographyComputer securityPhysical chemistryGeologyProgramming languageCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsOxidative Organic Chemistry Reactions