Highly Enantioselective Cobalt‐Catalyzed (3+2) Cycloadditions of Alkynylidenecyclopropanes
Eduardo da Concepción, Israel Fernández, José L. Mascareñas, Fernando López
Abstract
Abstract Low‐valent cobalt complexes equipped with chiral ligands can efficiently promote highly enantioselective (3+2) cycloadditions of alkyne‐tethered alkylidenecyclopropanes. The annulation allows to assemble bicyclic systems containing five‐membered rings in good yields and with excellent enantiomeric ratios. We also present a mechanistic discussion based on experimental and computational data, which support the involvement of Co I /Co III catalytic cycles.
Topics & Concepts
Enantioselective synthesisAnnulationCobaltCatalysisAlkyneBicyclic moleculeEnantiomerChemistryCombinatorial chemistryStereochemistryOrganic chemistryCyclopropane Reaction MechanismsCatalytic Alkyne ReactionsCatalytic C–H Functionalization Methods