Fe-Catalyzed Three-Component Coupling Reaction of α,β,γ,δ-Unsaturated Carbonyl Compounds and Conjugate Dienes with Alkylsilyl Peroxides and Nucleophiles
Hanbin Lu, Canhua Zhou, Zhe Wang, Terumasa Kato, Yan Liu, Keiji Maruoka
Abstract
-catalyzed three-component coupling reaction of α,β,γ,δ-unsaturated carbonyl compounds with alkylsilyl peroxides in the presence of certain heteronucleophiles (ROH and indole) is realized under mild reaction conditions. A variety of α,β,γ,δ-diene carbonyl substrates with different substituents were successfully employable via combination with several different alkylsilyl peroxides. This new approach is also applicable to the double functionalization of diene substrates.
Topics & Concepts
NucleophileDieneConjugateChemistryCatalysisCoupling reactionComponent (thermodynamics)Surface modificationCoupling (piping)Oxidative coupling of methaneOrganic chemistryPolymer chemistryMaterials sciencePhysical chemistryThermodynamicsMathematical analysisPhysicsNatural rubberMathematicsMetallurgyCatalytic C–H Functionalization MethodsAsymmetric Synthesis and CatalysisCatalytic Cross-Coupling Reactions