Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes
Dries Feyen, Wesley L. McKeithan, Arne A.N. Bruyneel, Sean Spiering, Larissa Hörmann, Bärbel Ulmer, Hui Zhang, Francesca Briganti, Michaela Schweizer, Bence Hegyi, Zhandi Liao, Risto-Pekka Pölönen, Kenneth S. Ginsburg, Chi Keung Lam, Ricardo Serrano, Christine Wahlquist, Alexander Kreymerman, Michelle M. Vu, Prashila Amatya, Charlotta Sophie Behrens, Sara Ranjbarvaziri, Renée G. C. Maas, Matthew Greenhaw, Daniel Bernstein, Joseph C. Wu, Donald M. Bers, Thomas Eschenhagen, Christian M. Metallo, Mark Mercola
Abstract
channel SCN5A and dilated cardiomyopathy due to a mutation in the RNA splicing factor RBM20. The maturation media should increase the fidelity of hiPSC-CMs as disease models.
Topics & Concepts
Induced pluripotent stem cellSarcomereEndoplasmic reticulumMyocyteCell biologyMutationCardiac fibrosisCardiomyopathyBiologyHeart failureInternal medicineGeneGeneticsMedicineEmbryonic stem cellCRISPR and Genetic EngineeringPluripotent Stem Cells ResearchNeuroscience and Neural Engineering