Transcriptomic identification of TMIGD1 and its relationship with the ileal epithelial cell differentiation in Crohn’s disease
Yamile Zabana, Violeta Lorén, Eugeni Domènech, Adrià Aterido, Arce García-Jaraquemada, Antonio Julià, María Vicario, Elisabet Pedrosa, Miriam Ferreiro, José M. Troya, Juan José Lozano, Maria‐Rosa Sarrias, Eduard Cabré, Míriam Mañosa, J Manyé
2020American Journal of Physiology-Gastrointestinal and Liver Physiology26 citationsDOIOpen Access PDF
Abstract
This is a single-center translational research study that aimed to look for key targets involved in Crohn's disease and define molecular pathways through different functional analysis strategies. With this approach, we have identified and described a novel target, the almost unknown TMIGD1 gene, which may be key in the recovery of injured mucosa involving intestinal epithelial cell differentiation.
Topics & Concepts
Identification (biology)TranscriptomeCrohn's diseaseDiseaseBiologyComputational biologyCrohn diseaseCellMedicinePathologyGeneticsGeneGene expressionBotanyInflammatory Bowel DiseaseEosinophilic EsophagitisGalectins and Cancer Biology